The main highlights of the session were:
- Formal opening of the Plenary Session and speech on The State of Regions and Cities in the European Union with:
- Vasco Alves Cordeiro, President of the European Committee of the Regions
- Elisa Ferreira, Commissioner for Cohesion and Reforms
- Pina Picierno (IT/S&D), Vice-President of the European Parliament
- Younous Omarjee (FR/The Left), Chair of the Committee on Regional Development of the European
- Debate on a health union that works for citizens in all EU territories with:
- Stella Kyriakides, Commissioner for Health and Food Safety
- Debate on the state of the regions and cities with:
- Francina Armengol, President of the Congress of Deputies of Spain
- Pierre-Yves Dermagne, Deputy Prime Minister and Minister for the Economy and Employment of Belgium
- Debate on the priorities of the Spanish Presidency of the Council of the EU with:
- Pascual Navarro Ríos, Secretary of State for the European Union
- Debate on local and regional authorities' support to Ukraine with:
- Leendert Verbeek, President of the Congress of Local and Regional Authorities
- Michael Gahler (DE/EPP), Member of the European Parliament
- Andriy Sadovyi, Mayor of Lviv, Ukraine
- Tetiana Yehorova-Lutsenko, President of the Ukrainian Association of District and Regional Councils